my.cnf for large database + high end server

#
# The MySQL database server configuration file for Large innodb database.
# This is one of my better my.cnf

[client]
port = 3306
socket = /var/run/mysqld/mysqld.sock

[mysqld_safe]
socket = /var/run/mysqld/mysqld.sock
nice = 0

[mysqld]

user = mysql
socket = /var/run/mysqld/mysqld.sock
port = 3306
basedir = /usr
datadir = /var/lib/mysql
tmpdir = /tmp
skip-external-locking
#skip-innodb
default-storage-engine=InnoDB
#
# Instead of skip-networking the default is now to listen only on
# localhost which is more compatible and is not less secure.
#bind-address = 127.0.0.1
#bind-address = 1.2.3.4
#
# * Fine Tuning
#
key_buffer = 192M
max_allowed_packet = 64M
thread_stack = 192K
thread_cache_size       = 64
# This replaces the startup script and checks MyISAM tables if needed
# the first time they are touched
myisam-recover         = BACKUP
max_connections        = 800

interactive_timeout= 5
wait_timeout= 5

log-slow-queries = /var/log/mysql/slow_query.log
long_query_time = 10

table_cache            = 6048
thread_concurrency     = 22

join_buffer_size = 64M
sort_buffer_size = 16M
max_heap_table_size = 4412M
max_connect_errors = 10
tmp_table_size = 4412M




#*** MyISAM Specific options
key_buffer_size = 64M
read_buffer_size = 4M
read_rnd_buffer_size = 8M

myisam_sort_buffer_size = 128M
#myisam_max_sort_file_size = 10G
#myisam_max_extra_sort_file_size = 10G



#finally added
table_definition_cache = 2048


#default-storage-engine = innodb
innodb_buffer_pool_size = 10000M
innodb_log_file_size = 1500M
innodb_flush_method = O_DIRECT #O_DSYNC
innodb_file_per_table = 1
innodb_flush_log_at_trx_commit = 2
innodb_log_buffer_size = 4M
innodb_additional_mem_pool_size = 20M

# num cpu's/cores *2 is a good base line for innodb_thread_concurrency
innodb_thread_concurrency = 16




#
# * Query Cache Configuration
#
query_cache_limit = 1M
query_cache_size  = 128M
query_cache_min_res_unit = 1k

#
# * Logging and Replication
#
# Both location gets rotated by the cronjob.
# Be aware that this log type is a performance killer.
# As of 5.1 you can enable the log at runtime!
#general_log_file        = /var/log/mysql/mysql.log
#general_log             = 1

log_error                = /var/log/mysql/error.log

#server-id = 1
#log_bin = /var/log/mysql/mysql-bin.log
expire_logs_days = 10
max_binlog_size         = 100M


[mysqldump]
quick
quote-names
max_allowed_packet = 16M

[mysql]
#no-auto-rehash # faster start of mysql but no tab completition

[isamchk]
key_buffer = 16M

!includedir /etc/mysql/conf.d/